URMC-099 facilitates amyloid-β clearance in a murine model of Alzheimer’s disease

BACKGROUND: The mixed lineage kinase type 3 inhibitor URMC-099 facilitates amyloid-beta (Aβ) clearance and degradation in cultured murine microglia. One putative mechanism is an effect of URMC-099 on Aβ uptake and degradation. As URMC-099 promotes endolysosomal protein trafficking and reduces Aβ mic...

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Bibliografiske detaljer
Udgivet i:J Neuroinflammation
Main Authors: Kiyota, Tomomi, Machhi, Jatin, Lu, Yaman, Dyavarshetty, Bhagyalaxmi, Nemati, Maryam, Zhang, Gang, Mosley, R. Lee, Gelbard, Harris A., Gendelman, Howard E.
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2018
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5935963/
https://ncbi.nlm.nih.gov/pubmed/29729668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-018-1172-y
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