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12-Lipoxygenase is a Critical Mediator of Type II Pneumocyte Senescence, Macrophage Polarization and Pulmonary Fibrosis after Irradiation

Radiation-induced pulmonary fibrosis (RIPF) is a chronic, progressive complication of therapeutic irradiation of the thorax. It has been suggested that senescence of type II pneumocytes (AECIIs), an alveolar stem cell, plays a role in the development of RIPF through loss of replicative reserve and v...

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Foilsithe in:Radiat Res
Main Authors: Chung, Eun Joo, Reedy, Jessica L., Kwon, Seokjoo, Patil, Shilpa, Valle, Luca, White, Ayla O., Citrin, Deborah E.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2019
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6816027/
https://ncbi.nlm.nih.gov/pubmed/31373871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1667/RR15356.1
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