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A gain of function paradox: Targeted therapy for glioblastoma associated with abnormal NHE9 expression

Glioblastoma (GBM) is the most frequent and inevitably lethal primary brain cancer in adults. It is recognized that the overexpression of the endosomal Na(+)/H(+) exchanger NHE9 is a potent driver of GBM progression. Patients with NHE9 overexpression have a threefold lower median survival relative t...

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Podrobná bibliografie
Vydáno v:J Cell Mol Med
Hlavní autoři: Pall, Ashley E., Juratli, Lena, Guntur, Dhyana, Bandyopadhyay, Krisanu, Kondapalli, Kalyan C.
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2019
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6815843/
https://ncbi.nlm.nih.gov/pubmed/31532058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.14665
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