Inflammation-induced Occludin Downregulation Limits Epithelial Apoptosis by Suppressing Caspase 3 Expression

BACKGROUND & AIMS: Epithelial tight junctions are compromised in patients with gastrointestinal disease. Occludin is a protein component of tight junctions; its removal from tight junctions or reduced expression results in barrier loss. Knockout (KO) of occludin in mice, however, does not appear...

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Udgivet i:Gastroenterology
Main Authors: Kuo, Wei-Ting, Shen, Le, Zuo, Li, Shashikanth, Nitesh, Ong, Ma. Lora Drizella M., Wu, Licheng, Zha, Juanmin, Edelblum, Karen L., Wang, Yitang, Wang, Yingmin, Nilsen, Steven P., Turner, Jerrold R.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6815722/
https://ncbi.nlm.nih.gov/pubmed/31401143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2019.07.058
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