Oncogenic KRAS Reduces Expression of FGF21 in Acinar Cells to Promote Pancreatic Tumorigenesis in Mice on a High-Fat Diet

BACKGROUND & AIMS: Obesity is a risk factor for pancreatic cancer. In mice, a high-fat diet (HFD) and expression of oncogenic KRAS lead to development of invasive pancreatic ductal adenocarcinoma (PDAC) by unknown mechanisms. We investigated how oncogenic KRAS regulates the expression of fibrobl...

Volledige beschrijving

Bewaard in:
Bibliografische gegevens
Gepubliceerd in:Gastroenterology
Hoofdauteurs: Luo, Yongde, Yang, Yaying, Liu, Muyun, Wang, Dan, Wang, Feng, Bi, Yawei, Ji, Juntao, Li, Suyun, Liu, Yan, Chen, Rong, Huang, Haojie, Wang, Xiaojie, Swidnicka-Siergiejko, Agnieszka K., Janowitz, Tobias, Beyaz, Semir, Wang, Guoqiang, Xu, Sulan, Bialkowska, Agnieszka B., Luo, Catherine K., Pin, Christoph L., Liang, Guang, Lu, Xiongbin, Wu, Maoxin, Shroyer, Kenneth R., Wolff, Robert A., Plunkett, William, Ji, Baoan, Li, Zhaoshen, Li, Ellen, Li, Xiaokun, Yang, Vincent W., Logsdon, Craig D., Abbruzzese, James L., Lu, Weiqin
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2019
Onderwerpen:
Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6815712/
https://ncbi.nlm.nih.gov/pubmed/31352001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2019.07.030
Tags: Voeg label toe
Geen labels, Wees de eerste die dit record labelt!

Gelijkaardige items