Obesogenic high-fat diet heightens aerobic glycolysis through hyperactivation of oncogenic KRAS

Abstract Oncogenic KRAS plays a vital role in controlling tumor metabolism by enhancing aerobic glycolysis. Obesity driven by chronic consumption of high-fat diet (HFD) is a major risk factor for oncogenic KRAS-mediated pancreatic ductal adenocarcinoma (PDAC). However, the role of HFD in KRAS-mediat...

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Detalhes bibliográficos
Main Authors: Dan Wang, Yawei Bi, Lianghao Hu, Yongde Luo, Juntao Ji, Albert Z. Mao, Craig D. Logsdon, Ellen Li, James L. Abbruzzese, Zhaoshen Li, Vincent W. Yang, Weiqin Lu
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2019-02-01
Colecção:Cell Communication and Signaling
Assuntos:
KRAS
Pancreatic cancer
Glycolysis
High-fat diet
Obesity
COX-2
Acesso em linha:http://link.springer.com/article/10.1186/s12964-019-0333-7
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