Lipid-targeting pleckstrin homology domain turns its autoinhibitory face toward the TEC kinases

The pleckstrin homology (PH) domain is well known for its phospholipid targeting function. The PH-TEC homology (PHTH) domain within the TEC family of tyrosine kinases is also a crucial component of the autoinhibitory apparatus. The autoinhibitory surface on the PHTH domain has been previously define...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Amatya, Neha, Wales, Thomas E., Kwon, Annie, Yeung, Wayland, Joseph, Raji E., Fulton, D. Bruce, Kannan, Natarajan, Engen, John R., Andreotti, Amy H.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2019
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6815127/
https://ncbi.nlm.nih.gov/pubmed/31591208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1907566116
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