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Late-stage trifluoromethylthiolation of benzylic C-H bonds
The benzylic positions in drugs are sites that readily react with cytochrome P450 oxidases via single-electron oxidation. New synthetic methodologies to incorporate a fluoroalkyl group at the benzylic site are continually being developed, and in this paper, we report a metal-free and site-selective...
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| Publicado no: | Nat Commun |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6814834/ https://ncbi.nlm.nih.gov/pubmed/31653853 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-12844-9 |
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