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Tau deposition is associated with functional isolation of the hippocampus in aging

The tau protein aggregates in aging and Alzheimer disease and may lead to memory loss through disruption of medial temporal lobe (MTL)-dependent memory systems. Here, we investigated tau-mediated mechanisms of hippocampal dysfunction that underlie the expression of episodic memory decline using fMRI...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Harrison, Theresa M., Maass, Anne, Adams, Jenna N., Du, Richard, Baker, Suzanne L., Jagust, William J.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2019
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6814780/
https://ncbi.nlm.nih.gov/pubmed/31653847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-12921-z
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