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Phase separation-deficient TDP43 remains functional in splicing
Intrinsically disordered regions (IDRs) are often fast-evolving protein domains of low sequence complexity that can drive phase transitions and are commonly found in many proteins associated with neurodegenerative diseases, including the RNA processing factor TDP43. Yet, how phase separation contrib...
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| Veröffentlicht in: | Nat Commun |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group UK
2019
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6814767/ https://ncbi.nlm.nih.gov/pubmed/31653829 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-12740-2 |
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