Disulfiram suppressed ethanol promoted RANKL-induced osteoclastogenesis in vitro and ethanol-induced osteoporosis in vivo via ALDH1A1-NFATc1 axis

Excessive alcohol consumption is positively related to osteoporosis, and its treatment strategies are poorly developed. Disulfiram inhibits receptor activator of nuclear factor kappa-B ligand (RANKL)-induced osteoclastogenesis; however, whether it can be used for ethanol-induced osteoclastogenesis a...

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Detalhes bibliográficos
Publicado no:Aging (Albany NY)
Main Authors: Jia, Yewei, Jiang, Jiawei, Zhao, Kangxian, Zhang, Tan, Sun, Peng, Peng, Jiaxuan, Yang, Qichang, Qian, Yu
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals 2019
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6814600/
https://ncbi.nlm.nih.gov/pubmed/31596733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.102279
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