Familial t(1;11) translocation is associated with disruption of white matter structural integrity and oligodendrocyte–myelin dysfunction

Although the underlying neurobiology of major mental illness (MMI) remains unknown, emerging evidence implicates a role for oligodendrocyte–myelin abnormalities. Here, we took advantage of a large family carrying a balanced t(1;11) translocation, which substantially increases risk of MMI, to underta...

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Published in:Mol Psychiatry
Main Authors: Vasistha, Navneet A., Johnstone, Mandy, Barton, Samantha K., Mayerl, Steffen E., Thangaraj Selvaraj, Bhuvaneish, Thomson, Pippa A., Dando, Owen, Grünewald, Ellen, Alloza, Clara, Bastin, Mark E., Livesey, Matthew R., Economides, Kyriakos, Magnani, Dario, Makedonopolou, Paraskevi, Burr, Karen, Story, David J., Blackwood, Douglas H. R., Wyllie, David J. A., McIntosh, Andrew M., Millar, J. Kirsty, ffrench-Constant, Charles, Hardingham, Giles E., Lawrie, Stephen M., Chandran, Siddharthan
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6814440/
https://ncbi.nlm.nih.gov/pubmed/31481758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41380-019-0505-2
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