Hypothermic Preconditioning Reverses Tau Ontogenesis in Human Cortical Neurons and is Mimicked by Protein Phosphatase 2A Inhibition

Hypothermia is potently neuroprotective, but the molecular basis of this effect remains obscure. Changes in neuronal tau protein are of interest, since tau becomes hyperphosphorylated in injury-resistant, hypothermic brains. Noting inter-species differences in tau isoforms, we have used functional c...

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Publicat a:EBioMedicine
Autors principals: Rzechorzek, Nina M., Connick, Peter, Livesey, Matthew R., Borooah, Shyamanga, Patani, Rickie, Burr, Karen, Story, David, Wyllie, David J.A., Hardingham, Giles E., Chandran, Siddharthan
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2015
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4739435/
https://ncbi.nlm.nih.gov/pubmed/26870825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2015.12.010
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