Hypothermic Preconditioning Reverses Tau Ontogenesis in Human Cortical Neurons and is Mimicked by Protein Phosphatase 2A Inhibition

Hypothermia is potently neuroprotective, but the molecular basis of this effect remains obscure. Changes in neuronal tau protein are of interest, since tau becomes hyperphosphorylated in injury-resistant, hypothermic brains. Noting inter-species differences in tau isoforms, we have used functional c...

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Vydáno v:EBioMedicine
Hlavní autoři: Rzechorzek, Nina M., Connick, Peter, Livesey, Matthew R., Borooah, Shyamanga, Patani, Rickie, Burr, Karen, Story, David, Wyllie, David J.A., Hardingham, Giles E., Chandran, Siddharthan
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2015
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4739435/
https://ncbi.nlm.nih.gov/pubmed/26870825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2015.12.010
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