Hypothermic Preconditioning of Human Cortical Neurons Requires Proteostatic Priming

Hypothermia is potently neuroprotective but poor mechanistic understanding has restricted its clinical use. Rodent studies indicate that hypothermia can elicit preconditioning, wherein a subtoxic cellular stress confers resistance to an otherwise lethal injury. The molecular basis of this preconditi...

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Detalhes bibliográficos
Publicado no:EBioMedicine
Main Authors: Rzechorzek, Nina Marie, Connick, Peter, Patani, Rickie, Selvaraj, Bhuvaneish Thangaraj, Chandran, Siddharthan
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2015
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4534756/
https://ncbi.nlm.nih.gov/pubmed/26287272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2015.04.004
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