Enhanced Bruton’s tyrosine kinase in B-cells and autoreactive IgA in patients with idiopathic pulmonary fibrosis

RATIONALE: Idiopathic Pulmonary Fibrosis (IPF) is thought to be triggered by repeated alveolar epithelial cell injury. Current evidence suggests that aberrant immune activation may contribute. However, the role of B-cell activation remains unclear. We determined the phenotype and activation status o...

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Publicat a:Respir Res
Autors principals: Heukels, Peter, van Hulst, Jennifer A. C., van Nimwegen, Menno, Boorsma, Carian E., Melgert, Barbro N., von der Thusen, Jan H., van den Blink, Bernt, Hoek, Rogier A. S., Miedema, Jelle R., Neys, Stefan F. H., Corneth, Odilia B. J., Hendriks, Rudi W., Wijsenbeek, Marlies S., Kool, Mirjam
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2019
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6814043/
https://ncbi.nlm.nih.gov/pubmed/31651327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12931-019-1195-7
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