Effect of N-Acetyltransferase 2 (NAT2) Genotype on the Pharmacokinetics of Hydralazine during Pregnancy

Hydralazine, an antihypertensive agent used during pregnancy, undergoes N-acetylation primarily via N-acetyltransferase 2 (NAT2) to form 3-methyl-1,2,4-triazolo[3,4-a]phthalazine (MTP). To characterize the steady-state pharmacokinetics (PK) of hydralazine during pregnancy and evaluate the effects of...

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Pubblicato in:J Clin Pharmacol
Autori principali: Han, Lyrialle W., Ryu, Rachel J., Cusumano, Michael, Easterling, Thomas R., Phillips, Brian R., Risler, Linda J., Shen, Danny D., Hebert, Mary F.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6813860/
https://ncbi.nlm.nih.gov/pubmed/31257615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcph.1477
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