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N-Acetyltransferase 2 Genotype-Dependent N-Acetylation of Hydralazine in Human Hepatocytes

Hydralazine is used in the treatment of essential hypertension and is under investigation for epigenetic therapy in the treatment of neoplastic and renal diseases. N-acetyltransferase (NAT) 2 exhibits a common genetic polymorphism in human populations. After recombinant expression in yeast, human NA...

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Dades bibliogràfiques
Publicat a:Drug Metab Dispos
Autors principals: Allen, Cecily E., Doll, Mark A., Hein, David W.
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Pharmacology and Experimental Therapeutics 2017
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5706087/
https://ncbi.nlm.nih.gov/pubmed/29018032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.117.078543
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