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Aldolase‐Catalyzed Asymmetric Synthesis of N‐Heterocycles by Addition of Simple Aliphatic Nucleophiles to Aminoaldehydes

Nitrogen heterocycles are structural motifs found in many bioactive natural products and of utmost importance in pharmaceutical drug development. In this work, a stereoselective synthesis of functionalized N‐heterocycles was accomplished in two steps, comprising the biocatalytic aldol addition of et...

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Publicat a:Adv Synth Catal
Autors principals: Roldán, Raquel, Hernández, Karel, Joglar, Jesús, Bujons, Jordi, Parella, Teodor, Fessner, Wolf‐Dieter, Clapés, Pere
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2019
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6813633/
https://ncbi.nlm.nih.gov/pubmed/31680790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/adsc.201801530
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