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Reversible Spatiotemporal Control of Induced Protein Degradation by Bistable PhotoPROTACs
[Image: see text] Off-tissue effects are persistent issues of modern inhibition-based therapies. By merging the strategies of photopharmacology and small-molecule degraders, we introduce a novel concept for persistent spatiotemporal control of induced protein degradation that potentially prevents of...
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| Publicat a: | ACS Cent Sci |
|---|---|
| Autors principals: | , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Chemical Society
2019
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| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6813558/ https://ncbi.nlm.nih.gov/pubmed/31660436 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscentsci.9b00713 |
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