Antigenicity of tissues and organs from GGTA1/CMAH/β4GalNT2 triple gene knockout pigs

Clinical xenotransplantations have been hampered by human preformed antibody-mediated damage of the xenografts. To overcome biological incompatibility between pigs and humans, one strategy is to remove the major antigens [Gal, Neu5Gc, and Sd(a)] present on pig cells and tissues. Triple gene (GGTA1,...

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Pubblicato in:J Biomed Res
Autori principali: Wang, Ronggen, Ruan, Miaomiao, Zhang, Runjie, Chen, Lei, Li, Xiaoxue, Fang, Bin, Li, Chu, Ren, Xueyang, Liu, Jiying, Xiong, Qiang, Zhang, Lining, Jin, Yong, Li, Lin, Li, Rongfeng, Wang, Ying, Yang, Haiyuan, Dai, Yifan
Natura: Artigo
Lingua:Inglês
Pubblicazione: Editorial Department of Journal of Biomedical Research 2019
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6813527/
https://ncbi.nlm.nih.gov/pubmed/30007952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7555/JBR.32.20180018
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