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Reduced binding of human antibodies to cells from GGTA1/CMAH knockout pigs
Xenotransplantation using genetically modified pig organs could solve the donor organ shortage problem. Two inactivated genes that make humans unique from pigs are GGTA1 and CMAH, the products of which produce the carbohydrate epitopes, aGal and Neu5Gc that attract preformed human antibody. When the...
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| Publicado no: | Am J Transplant |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4366649/ https://ncbi.nlm.nih.gov/pubmed/24909344 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/ajt.12744 |
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