Reduced binding of human antibodies to cells from GGTA1/CMAH knockout pigs

Xenotransplantation using genetically modified pig organs could solve the donor organ shortage problem. Two inactivated genes that make humans unique from pigs are GGTA1 and CMAH, the products of which produce the carbohydrate epitopes, aGal and Neu5Gc that attract preformed human antibody. When the...

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Udgivet i:Am J Transplant
Main Authors: Burlak, C., Paris, L.L., Lutz, A.J., Sidner, R.A., Estrada, J., Li, P., Tector, M., Tector, A.J.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4366649/
https://ncbi.nlm.nih.gov/pubmed/24909344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/ajt.12744
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