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High-performance chemical- and light-inducible recombinases in mammalian cells and mice

Site-specific DNA recombinases are important genome engineering tools. Chemical- and light-inducible recombinases, in particular, enable spatiotemporal control of gene expression. However, inducible recombinases are scarce due to the challenge of engineering high performance systems, thus constraini...

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Pubblicato in:Nat Commun
Autori principali: Weinberg, Benjamin H., Cho, Jang Hwan, Agarwal, Yash, Pham, N. T. Hang, Caraballo, Leidy D., Walkosz, Maciej, Ortega, Charina, Trexler, Micaela, Tague, Nathan, Law, Billy, Benman, William K. J., Letendre, Justin, Beal, Jacob, Wong, Wilson W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2019
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6813296/
https://ncbi.nlm.nih.gov/pubmed/31649244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-12800-7
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