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3389 Coagulation Factor Xll-mediated contact system and its role in adaptive and innate immune cell movement

OBJECTIVES/SPECIFIC AIMS: The objectives of this study are to 1) expand upon the paradigm of HK-D5 accelerated immune cell chemotaxis; 2) characterize the role of FXII in murine models of immune-mediated disease using FXII KO mice and a small molecule inhibitor of FXIIa. METHODS/STUDY POPULATION: To...

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Detalhes bibliográficos
Publicado no:J Clin Transl Sci
Main Authors: Beltran, Emily, Smith, Tukisa, Graczyk, Beth, Breslow, Jan, Ponda, Manish
Formato: Artigo
Idioma:Inglês
Publicado em: Cambridge University Press 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6812876/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1017/cts.2019.16
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