3389 Coagulation Factor Xll-mediated contact system and its role in adaptive and innate immune cell movement

OBJECTIVES/SPECIFIC AIMS: The objectives of this study are to 1) expand upon the paradigm of HK-D5 accelerated immune cell chemotaxis; 2) characterize the role of FXII in murine models of immune-mediated disease using FXII KO mice and a small molecule inhibitor of FXIIa. METHODS/STUDY POPULATION: To...

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Veröffentlicht in:J Clin Transl Sci
Hauptverfasser: Beltran, Emily, Smith, Tukisa, Graczyk, Beth, Breslow, Jan, Ponda, Manish
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cambridge University Press 2019
Schlagworte:
Basic/Translational Science/Team Science
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6812876/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1017/cts.2019.16
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