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Reduced P2X receptor levels are associated with antidepressant effect in the learned helplessness model

Purinergic receptors, especially P2RX, are associated to the severity of symptoms in patients suffering from depressive and bipolar disorders, and genetic deletion or pharmacological blockade of P2RX7 induces antidepressant-like effect in preclinical models. However, there is scarce evidence about t...

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Dades bibliogràfiques
Publicat a:PeerJ
Autors principals: Ribeiro, Deidiane Elisa, Casarotto, Plinio C., Staquini, Laura, Pinto e Silva, Maria Augusta, Biojone, Caroline, Wegener, Gregers, Joca, Samia
Format: Artigo
Idioma:Inglês
Publicat: PeerJ Inc. 2019
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6812674/
https://ncbi.nlm.nih.gov/pubmed/31656696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7717/peerj.7834
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