Antidepressant-like effect induced by systemic and intra-hippocampal administration of DNA methylation inhibitors

BACKGROUND AND PURPOSE: Epigenetic modifications are thought to play an important role in the neurobiology of depression. Antidepressant treatment induces histone acetylation in the hippocampus, which is associated with transcriptional activation, whereas stress increases DNA methylation, which is a...

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Detalhes bibliográficos
Main Authors: Sales, Amanda J, Biojone, Caroline, Terceti, Mateus S, Guimarães, Francisco S, Gomes, Marcus VM, Joca, Sâmia RL
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2011
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3230817/
https://ncbi.nlm.nih.gov/pubmed/21585346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2011.01489.x
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