Crafting Carbazole-Based Vorinostat and Tubastatin-A-like Histone Deacetylase (HDAC) Inhibitors with Potent in Vitro and in Vivo Neuroactive Functions

[Image: see text] Small-molecule inhibitors of HDACs (HDACi) induce hyperacetylation of histone and nonhistone proteins and have emerged as potential therapeutic agents in most animal models tested. The established HDACi vorinostat and tubastatin-A alleviate neurodegenerative and behavioral conditio...

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Publicat a:ACS Omega
Autors principals: Reddy, R. Gajendra, Surineni, Goverdhan, Bhattacharya, Dwaipayan, Marvadi, Sandeep Kumar, Sagar, Arpita, Kalle, Arunasree M., Kumar, Arvind, Kantevari, Srinivas, Chakravarty, Sumana
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2019
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6811854/
https://ncbi.nlm.nih.gov/pubmed/31656902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsomega.9b01950
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