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Crafting Carbazole-Based Vorinostat and Tubastatin-A-like Histone Deacetylase (HDAC) Inhibitors with Potent in Vitro and in Vivo Neuroactive Functions
[Image: see text] Small-molecule inhibitors of HDACs (HDACi) induce hyperacetylation of histone and nonhistone proteins and have emerged as potential therapeutic agents in most animal models tested. The established HDACi vorinostat and tubastatin-A alleviate neurodegenerative and behavioral conditio...
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| 出版年: | ACS Omega |
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| 主要な著者: | , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Chemical Society
2019
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| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6811854/ https://ncbi.nlm.nih.gov/pubmed/31656902 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsomega.9b01950 |
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