Amikacin Initial Dose in Critically Ill Patients: a Nonparametric Approach To Optimize A Priori Pharmacokinetic/Pharmacodynamic Target Attainments in Individual Patients

Amikacin is commonly used for probabilistic antimicrobial therapy in critically ill patients with sepsis. Its narrow therapeutic margin makes it challenging to determine the right individual dose that ensures the highest efficacy target attainment rate (TAR) in this setting. This study aims to devel...

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發表在:Antimicrob Agents Chemother
Main Authors: Boidin, Clément, Bourguignon, Laurent, Cohen, Sabine, Roger, Claire, Lefrant, Jean-Yves, Roberts, Jason A., Allaouchiche, Bernard, Lepape, Alain, Friggeri, Arnaud, Goutelle, Sylvain
格式: Artigo
語言:Inglês
出版: American Society for Microbiology 2019
主題:
Pharmacology
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6811403/
https://ncbi.nlm.nih.gov/pubmed/31481443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00993-19
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