Synergistic Meropenem-Tobramycin Combination Dosage Regimens against Clinical Hypermutable Pseudomonas aeruginosa at Simulated Epithelial Lining Fluid Concentrations in a Dynamic Biofilm Model

Exacerbations of chronic Pseudomonas aeruginosa infections are a major treatment challenge in cystic fibrosis due to biofilm formation and hypermutation. We aimed to evaluate different dosage regimens of meropenem and tobramycin as monotherapies and in combination against hypermutable carbapenem-res...

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Vydáno v:Antimicrob Agents Chemother
Hlavní autoři: Bilal, Hajira, Bergen, Phillip J., Kim, Tae Hwan, Chung, Seung Eun, Peleg, Anton Y., Oliver, Antonio, Nation, Roger L., Landersdorfer, Cornelia B.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2019
Témata:
Pharmacology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6811397/
https://ncbi.nlm.nih.gov/pubmed/31427301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01293-19
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