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Synergistic Meropenem-Tobramycin Combination Dosage Regimens against Clinical Hypermutable Pseudomonas aeruginosa at Simulated Epithelial Lining Fluid Concentrations in a Dynamic Biofilm Model

Exacerbations of chronic Pseudomonas aeruginosa infections are a major treatment challenge in cystic fibrosis due to biofilm formation and hypermutation. We aimed to evaluate different dosage regimens of meropenem and tobramycin as monotherapies and in combination against hypermutable carbapenem-res...

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Bibliografski detalji
Izdano u:Antimicrob Agents Chemother
Glavni autori: Bilal, Hajira, Bergen, Phillip J., Kim, Tae Hwan, Chung, Seung Eun, Peleg, Anton Y., Oliver, Antonio, Nation, Roger L., Landersdorfer, Cornelia B.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2019
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Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6811397/
https://ncbi.nlm.nih.gov/pubmed/31427301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01293-19
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