Synergistic Meropenem-Tobramycin Combination Dosage Regimens against Clinical Hypermutable Pseudomonas aeruginosa at Simulated Epithelial Lining Fluid Concentrations in a Dynamic Biofilm Model

Exacerbations of chronic Pseudomonas aeruginosa infections are a major treatment challenge in cystic fibrosis due to biofilm formation and hypermutation. We aimed to evaluate different dosage regimens of meropenem and tobramycin as monotherapies and in combination against hypermutable carbapenem-res...

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Detalles Bibliográficos
Publicado en:Antimicrob Agents Chemother
Main Authors: Bilal, Hajira, Bergen, Phillip J., Kim, Tae Hwan, Chung, Seung Eun, Peleg, Anton Y., Oliver, Antonio, Nation, Roger L., Landersdorfer, Cornelia B.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2019
Assuntos:
Pharmacology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6811397/
https://ncbi.nlm.nih.gov/pubmed/31427301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01293-19
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