Clinically Relevant Epithelial Lining Fluid Concentrations of Meropenem with Ciprofloxacin Provide Synergistic Killing and Resistance Suppression of Hypermutable Pseudomonas aeruginosa in a Dynamic Biofilm Model

Treatment of exacerbations of chronic Pseudomonas aeruginosa infections in patients with cystic fibrosis (CF) is highly challenging due to hypermutability, biofilm formation, and an increased risk of resistance emergence. We evaluated the impact of ciprofloxacin and meropenem as monotherapy and in c...

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Vydáno v:Antimicrob Agents Chemother
Hlavní autoři: Bilal, Hajira, Bergen, Phillip J., Tait, Jessica R., Wallis, Steven C., Peleg, Anton Y., Roberts, Jason A., Oliver, Antonio, Nation, Roger L., Landersdorfer, Cornelia B.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2020
Témata:
Pharmacology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7318014/
https://ncbi.nlm.nih.gov/pubmed/32366710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00469-20
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