2500. Fostemsavir Drug–Drug Interaction Profile, an Attachment Inhibitor and Oral Prodrug of Temsavir, for Heavily Treatment Experienced HIV-1-Infected Patients

BACKGROUND: Fostemsavir (FTR) is a first-in-class attachment inhibitor being evaluated in heavily treatment-experienced (HTE) HIV-1-infected patients. Active temsavir (TMR) binds to viral envelope glycoprotein 120 and prevents viral attachment and entry into host CD4+ T cells. TMR is primarily metab...

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發表在:Open Forum Infect Dis
Main Authors: Moore, Katy P, Mageau, A Savannah, Magee, Mindy, Gorycki, Peter D, Ackerman, Peter, Llamoso, Cyril
格式: Artigo
語言:Inglês
出版: Oxford University Press 2019
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6810480/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ofid/ofz360.2178
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