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Revealing a Mutant-Induced Receptor Allosteric Mechanism for the Thyroid Hormone Resistance
Resistance to thyroid hormone (RTH) is a clinical disorder without specific and effective therapeutic strategy, partly due to the lack of structural mechanisms for the defective ligand binding by mutated thyroid hormone receptors (THRs). We herein uncovered the prescription drug roxadustat as a nove...
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| Publicado no: | iScience |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Elsevier
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6806671/ https://ncbi.nlm.nih.gov/pubmed/31655060 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2019.10.002 |
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