Revealing a Mutant-Induced Receptor Allosteric Mechanism for the Thyroid Hormone Resistance

Resistance to thyroid hormone (RTH) is a clinical disorder without specific and effective therapeutic strategy, partly due to the lack of structural mechanisms for the defective ligand binding by mutated thyroid hormone receptors (THRs). We herein uncovered the prescription drug roxadustat as a nove...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:iScience
Main Authors: Yao, Benqiang, Wei, Yijuan, Zhang, Shuchi, Tian, Siyu, Xu, Shuangshuang, Wang, Rui, Zheng, Weili, Li, Yong
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2019
Assuntos:
Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6806671/
https://ncbi.nlm.nih.gov/pubmed/31655060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2019.10.002
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares