Intranasal Coadministration of a Diazepam Prodrug with a Converting Enzyme Results in Rapid Absorption of Diazepam in Rats

Intranasal administration is an attractive route for systemic delivery of small, lipophilic drugs because they are rapidly absorbed through the nasal mucosa into systemic circulation. However, the low solubility of lipophilic drugs often precludes aqueous nasal spray formulations. A unique approach...

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Опубликовано в: :J Pharmacol Exp Ther
Главные авторы: Rautiola, Davin, Maglalang, Patricia D., Cheryala, Narsihmulu, Nelson, Kathryn M., Georg, Gunda I., Fine, Jared M., Svitak, Aleta L., Faltesek, Katherine A., Hanson, Leah R., Mishra, Usha, Coles, Lisa D., Cloyd, James C., Siegel, Ronald A.
Формат: Artigo
Язык:Inglês
Опубликовано: The American Society for Pharmacology and Experimental Therapeutics 2019
Предметы:
Special Issue on Drug Delivery Technologies
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6806351/
https://ncbi.nlm.nih.gov/pubmed/30837282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.118.255943
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