Intranasal Coadministration of a Diazepam Prodrug with a Converting Enzyme Results in Rapid Absorption of Diazepam in Rats

Intranasal administration is an attractive route for systemic delivery of small, lipophilic drugs because they are rapidly absorbed through the nasal mucosa into systemic circulation. However, the low solubility of lipophilic drugs often precludes aqueous nasal spray formulations. A unique approach...

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Bibliografiske detaljer
Udgivet i:J Pharmacol Exp Ther
Main Authors: Rautiola, Davin, Maglalang, Patricia D., Cheryala, Narsihmulu, Nelson, Kathryn M., Georg, Gunda I., Fine, Jared M., Svitak, Aleta L., Faltesek, Katherine A., Hanson, Leah R., Mishra, Usha, Coles, Lisa D., Cloyd, James C., Siegel, Ronald A.
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Pharmacology and Experimental Therapeutics 2019
Fag:
Special Issue on Drug Delivery Technologies
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6806351/
https://ncbi.nlm.nih.gov/pubmed/30837282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.118.255943
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