Intranasal Coadministration of a Diazepam Prodrug with a Converting Enzyme Results in Rapid Absorption of Diazepam in Rats

Intranasal administration is an attractive route for systemic delivery of small, lipophilic drugs because they are rapidly absorbed through the nasal mucosa into systemic circulation. However, the low solubility of lipophilic drugs often precludes aqueous nasal spray formulations. A unique approach...

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Bibliografiska uppgifter
I publikationen:J Pharmacol Exp Ther
Huvudupphovsmän: Rautiola, Davin, Maglalang, Patricia D., Cheryala, Narsihmulu, Nelson, Kathryn M., Georg, Gunda I., Fine, Jared M., Svitak, Aleta L., Faltesek, Katherine A., Hanson, Leah R., Mishra, Usha, Coles, Lisa D., Cloyd, James C., Siegel, Ronald A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: The American Society for Pharmacology and Experimental Therapeutics 2019
Ämnen:
Special Issue on Drug Delivery Technologies
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6806351/
https://ncbi.nlm.nih.gov/pubmed/30837282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.118.255943
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