Antibodies Predict Pegaspargase Allergic Reactions and Failure of Rechallenge

PURPOSE: Pegaspargase (PEG-ASP) has largely replaced native Escherichia coli asparaginase (L-ASP) in the treatment of acute lymphoblastic leukemia because of its longer half-life and lower immunogenicity. Risk factors for allergic reactions to PEG-ASP remain unclear. Here, we identify risk factors f...

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Detalhes bibliográficos
Publicado no:J Clin Oncol
Main Authors: Liu, Yiwei, Smith, Colton A., Panetta, John C., Yang, Wenjian, Thompson, Lauren E., Counts, Jacob P., Molinelli, Alejandro R., Pei, Deqing, Kornegay, Nancy M., Crews, Kristine R., Swanson, Hope, Cheng, Cheng, Karol, Seth E., Evans, William E., Inaba, Hiroto, Pui, Ching-Hon, Jeha, Sima, Relling, Mary V.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Clinical Oncology 2019
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ORIGINAL REPORTS
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6804844/
https://ncbi.nlm.nih.gov/pubmed/31188727
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.18.02439
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