2251: An estrogen receptor α (ERα)-BMPR2-apelin axis mediates 17β-estradiol’s protective effects on right ventricular function in experimental pulmonary hypertension (PH)

OBJECTIVES/SPECIFIC AIMS: Women with pulmonary arterial hypertension (PAH) exhibit superior right ventricular (RV) function and survival compared with men, a phenomenon attributed to poorly understood cardioprotective effects of 17β-estradiol (E2). We hypothesize that E2, through ERα, attenuates PH-...

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Gepubliceerd in:J Clin Transl Sci
Hoofdauteurs: Lee Frump, Andrea, Albrecht, Margie, Breuils-Bonnet, Sandra, Yakubov, Bakhtiyor, Beth Brown, Mary, Provencher, Steeve, Bonnet, Sebastien, Lahm, Tim
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Cambridge University Press 2018
Onderwerpen:
Mechanistic Basic to Clinical
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6804580/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1017/cts.2017.214
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