MCC1019, a selective inhibitor of the Polo-box domain of Polo-like kinase 1 as novel, potent anticancer candidate

Polo-like kinase (PLK1) has been identified as a potential target for cancer treatment. Although a number of small molecules have been investigated as PLK1 inhibitors, many of which showed limited selectivity. PLK1 harbors a regulatory domain, the Polo box domain (PBD), which has a key regulatory fu...

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Detalhes bibliográficos
Publicado no:Acta Pharm Sin B
Main Authors: Abdelfatah, Sara, Berg, Angela, Huang, Qi, Yang, Li Jun, Hamdoun, Sami, Klinger, Anette, Greten, Henry J., Fleischer, Edmond, Berg, Thorsten, Wong, Vincent K.W., Efferth, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2019
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Original article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6804483/
https://ncbi.nlm.nih.gov/pubmed/31649851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.apsb.2019.02.001
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