Orthogonal assays for the identification of inhibitors of the single-stranded nucleic acid binding protein YB-1

We have previously shown that high expression of the nucleic acid binding factor YB-1 is strongly associated with poor prognosis in a variety of cancer types. The 3-dimensional protein structure of YB-1 has yet to be determined and its role in transcriptional regulation remains elusive. Drug targeti...

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Detalhes bibliográficos
Publicado no:Acta Pharm Sin B
Main Authors: Trevarton, AlexanderJ., Zhou, Yan, Yang, Dehua, Rewcastle, Gordon W., Flanagan, Jack U., Braithwaite, Antony, Shepherd, Peter R., Print, Cristin G., Wang, Ming-Wei, Lasham, Annette
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2019
Assuntos:
Original article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6804448/
https://ncbi.nlm.nih.gov/pubmed/31649849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.apsb.2018.12.011
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