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Orthogonal assays for the identification of inhibitors of the single-stranded nucleic acid binding protein YB-1

We have previously shown that high expression of the nucleic acid binding factor YB-1 is strongly associated with poor prognosis in a variety of cancer types. The 3-dimensional protein structure of YB-1 has yet to be determined and its role in transcriptional regulation remains elusive. Drug targeti...

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Detalhes bibliográficos
Main Authors: AlexanderJ. Trevarton, Yan Zhou, Dehua Yang, Gordon W. Rewcastle, Jack U. Flanagan, Antony Braithwaite, Peter R. Shepherd, Cristin G. Print, Ming-Wei Wang, Annette Lasham
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2019-09-01
Colecção:Acta Pharmaceutica Sinica B
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2211383518310050
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