Dendritic Cells Require PINK1-Mediated Phosphorylation of BCKDE1α to Promote Fatty Acid Oxidation for Immune Function

Dendritic cell (DCs) activation by Toll-like receptor (TLR) agonist induces robust metabolic rewiring toward glycolysis. Recent findings in the field identified mechanistic details governing these metabolic adaptations. However, it is unknown whether a switch to glycolysis from oxidative phosphoryla...

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Bibliographic Details
Published in:Front Immunol
Main Authors: Basit, Farhan, de Vries, I. Jolanda M.
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2019
Subjects:
Immunology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6803436/
https://ncbi.nlm.nih.gov/pubmed/31681280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.02386
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