Potential roles of PINK1 for increased PGC-1α-mediated mitochondrial fatty acid oxidation and their associations with Alzheimer disease and diabetes

Down-regulation of PINK1 and PGC-1α proteins is implicated in both mitochondrial dysfunction and oxidative stress potentially linking metabolic abnormality and neurodegeneration. Here, we report that PGC-1α and PINK1 expression is markedly decreased in Alzheimer disease (AD) and diabetic brains. We...

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Detaylı Bibliyografya
Yayımlandı:Mitochondrion
Asıl Yazarlar: Choi, Joungil, Ravipati, Avinash, Nimmagadda, Vamshi, Schubert, Manfred, Castellani, Rudolph J., Russell, James W.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2014
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4911223/
https://ncbi.nlm.nih.gov/pubmed/25260493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mito.2014.09.005
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