Increased stress associated with head-out plethysmography testing can exacerbate respiratory effects and lead to mortality in rats

INTRODUCTION: DSM421, a dihydroorotate dehydrogenase inhibitor, was in preclinical development as a potential treatment option for malaria. When tested in a core battery of safety pharmacology assays, DSM421 did not produce any effects at oral doses up to 750 mg/kg in an Irwin test in rats, but a re...

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發表在:J Pharmacol Toxicol Methods
Main Authors: Lynch, James J., Rossignol, Emilie, Moehrle, Joerg J., Van Vleet, Terry R., Marsh, Kennan C., Parman, Toufan, Mirsalis, Jon, Ottinger, Sean E., Segreti, Jason A., Rao, Mohan, Mittelstadt, Scott W.
格式: Artigo
語言:Inglês
出版: 2019
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6803055/
https://ncbi.nlm.nih.gov/pubmed/31085318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vascn.2019.106580
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