Alloactivation of Naïve CD4(+)CD8(−)CD25(+)T Regulatory Cells: Expression of CD8α Identifies Potent Suppressor Cells That Can Promote Transplant Tolerance Induction

Therapy with alloantigen-specific CD4(+)CD25(+) T regulatory cells (Treg) for induction of transplant tolerance is desirable, as naïve thymic Treg (tTreg) are not alloantigen-specific and are weak suppressor cells. Naïve tTreg from DA rats cultured with fully allogeneic PVG stimulator cells in the p...

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Détails bibliographiques
Publié dans:Front Immunol
Auteurs principaux: Verma, Nirupama D., Robinson, Catherine M., Carter, Nicole, Wilcox, Paul, Tran, Giang T., Wang, Chaunmin, Sharland, Alexandra, Nomura, Masaru, Plain, Karren M., Bishop, G. Alexander, Hodgkinson, Suzanne J., Hall, Bruce M.
Format: Artigo
Langue:Inglês
Publié: Frontiers Media S.A. 2019
Sujets:
Immunology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6802415/
https://ncbi.nlm.nih.gov/pubmed/31681288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.02397
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