Transforming Growth Factor-β1 Selectively Recruits microRNAs to the RNA-Induced Silencing Complex and Degrades CFTR mRNA under Permissive Conditions in Human Bronchial Epithelial Cells

Mutations in the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene lead to cystic fibrosis (CF). The most common mutation F508del inhibits folding and processing of CFTR protein. FDA-approved correctors rescue the biosynthetic processing of F508del-CFTR protein, while potentiators impr...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Mitash, Nilay, Mu, Fangping, Donovan, Joshua E., Myerburg, Michael M., Ranganathan, Sarangarajan, Greene, Catherine M., Swiatecka-Urban, Agnieszka
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6801718/
https://ncbi.nlm.nih.gov/pubmed/31590401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20194933
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