Precise Targeting of miRNA Sites Restores CFTR Activity in CF Bronchial Epithelial Cells

MicroRNAs that are overexpressed in cystic fibrosis (CF) bronchial epithelial cells (BEC) negatively regulate CFTR and nullify the beneficial effects of CFTR modulators. We hypothesized that it is possible to reverse microRNA-mediated inhibition of CFTR using CFTR-specific target site blockers (TSBs...

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Detalhes bibliográficos
Publicado no:Mol Ther
Main Authors: De Santi, Chiara, Fernández Fernández, Elena, Gaul, Rachel, Vencken, Sebastian, Glasgow, Arlene, Oglesby, Irene K., Hurley, Killian, Hawkins, Finn, Mitash, Nilay, Mu, Fangping, Raoof, Rana, Henshall, David C., Cutrona, Meritxell B., Simpson, Jeremy C., Harvey, Brian J., Linnane, Barry, McNally, Paul, Cryan, Sally Ann, MacLoughlin, Ronan, Swiatecka-Urban, Agnieszka, Greene, Catherine M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Gene & Cell Therapy 2020
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7132615/
https://ncbi.nlm.nih.gov/pubmed/32059764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2020.02.001
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