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Tgf-β1 Inhibits Cftr Biogenesis and Prevents Functional Rescue of ΔF508-Cftr in Primary Differentiated Human Bronchial Epithelial Cells
CFTR is an integral transmembrane glycoprotein and a cAMP-activated Cl(−) channel. Mutations in the CFTR gene lead to Cystic Fibrosis (CF)–an autosomal recessive disease with majority of the morbidity and mortality resulting from airway infection, inflammation, and fibrosis. The most common disease-...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
Public Library of Science
2013
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3650079/ https://ncbi.nlm.nih.gov/pubmed/23671668 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0063167 |
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